PUXANO is seeking a highly experienced and motivated Senior Scientist to join our team. The successful candidate will have extensive expertise in structural biology and protein engineering/design linked to cryo electron microscopy (single particle analysis or tomography). Part of your job will be to fuel our innovation pipeline of projects that can accelerate Gene-to-Structure or Design-to-Structure research. This includes developing and testing new methods, providing research services to PUXANO customers, managing internal and collaborative research projects with academic and industrial partners in method development, applying for competitive research grants, giving talks to different audiences.
Protein Design:
– Retrieve and assemble data from various protein information databases.
– Select design strategies and tools for in silico protein design and validation.
– Proficient in using cutting-edge protein design tools, including AlphaFold2, OpenFold, ESM, ProteinMPNN, RF Diffusion, Genie, and different protein language models.
– Experienced in setting up automated pipelines for in silico validation of protein designs.
– Skilled in experimental validation workflows, from high-throughput cloning and expression to purification and biophysical characterization.
Cryo-Electron Microscopy:
– Expertise in cryo-EM sample preparation and data collection using EPU or SerialEM.
– Proficient in cryo-EM data processing with tools like Relion, Scipion, and other open-source software.
Research and Innovation:
– Stay at the forefront of advancements in protein design, expression, purification, and structural biology.
– Lead innovative research projects to enhance PUXANO’s capabilities.
– Publish research in peer-reviewed journals and present at scientific conferences.
Collaboration and Communication:
– Collaborate with internal teams and external partners in Pharma and Biotech.
– Effectively communicate complex technical concepts to both technical and non-technical audiences.
– Contribute to grant writing and funding proposals for ongoing research initiatives.
– Ph.D. in Structural Biology, computational Biology, Biochemistry, Biotechnology, or a related field.
– Extensive experience in protein design and engineering coupled to experimental validation using cryoEM.
– Proven expertise in protein purification and analysis using techniques such as SDS-PAGE, Western blotting, IMAC, SEC, BLI and MALLS.
– Excellent problem-solving skills and a track record of innovative research.– Strong communication skills and the ability to work collaboratively in a fast-paced, interdisciplinary environment.
Interested candidates should submit a resume, cover letter, and contact information for three references to careers@puxano.com.
PUXANO is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Application Deadline: November 2024
Join PUXANO and be a part of a pioneering team that’s shaping the future of protein design and structure-based research!
