Puxano - Puxano protein research services

PUXANO Service Packages

Our stand-alone services

We offer stand-alone service packages tailored for recurrent protein analysis within the gene-to-structure or design-to-structure workflow. To get started, please contact us with th elink below regarding the number of samples and the type of analysis that is requested. AFter that we will send you a simple form that you need to respond respond to a fixed set of questions. Within two days, you’ll receive a detailed quote along with a potential execution timeline. Depending on the type of analysis and the number of samples, results can be expected within 2-4 weeks.

Our service packages include:

– High-throughput protein expression, production, and biophysical characterization to support antigen design campaigns.

– Protein sample screening and structure determination using our proprietary PUXANO cryoEM grids.

– Nanoparticle analysis utilizing advanced cryoEM techniques.

Our service packages

Structural Bioinformatics

Using a combination of predictive AI-tools, bioinformatic sequence analysis and molecular simulations, we perform extensive in silico analysis of your protein(s) of interest. This information provides substantial value for applications like vaccine design, protein production or protein engineering.

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CryoEM Grid Screening

Using the PXN grid portfolio we can quickly screen which grid works best for your specific target protein structure determination using cryoEM. This includes PXN holey grids and PXN graphene grids whereby we vary hole size, film thickness, grid material and surface functionalization.

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Nanoparticle Quality Control.

We perform a visual inspection of nanoparticles using negative stain and cryo-electron microscopy supplemented with advanced image processing. The latter enables us to qualitatively and/or quantitatively assess particle homogeneity, morphology, size, particle load, etc.

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Protein-protein interaction profiling

We analyze protein-ligand or protein-protein complex formation by monitoring affinity, kinetics, stoichiometry or thermodynamic profiles.

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Applications

Vaccine Design

In silico design of protein target variations with enhanced immunogenicity followed by high throughput expression, production and qualitative analysis using protein interaction and stability tests to select a reduced set of optimized core antigen variants.