Unlocking challenging protein targets

PUXANO is trusted by pharmaceutical and biotech leaders worldwide to drive structure-based protein research, enabling breakthroughs in vaccine and antibody development and small-molecule drug screening.

Our key mission is to make challenging targets accessible via a powerful discovery platform that seamlessly integrates in silico protein design with advanced nanotechnological and biotechnological tools for in-depth experimental research.  

The PROCONDOR platform

PUXANO has developed a proprietary technology platform which fuses biotechnology, nanotechnology, and AI to revolutionize protein design and structure-based research to get access to those challenging targets where standard workflows fail, such as outer membrane proteins, glycoproteins, GPCRs, ion channels and fragile protein complexes. 

We have build a protein design toolbox for generating soluble analogues, multimer-stabilizing scaffolds, multi-epitope scaffolds, multimer-generating scaffolds or fiducials to build antigens for vaccine and antibody development, facilitate high-throughput drug screening or accelerate structure-guided drug development. 

Via our cryoEM grid portfolio, we can overcome major problems in cryoEM sample preparation: low sample yields, complex dissassembly or preferred particle orientation. Furthermore, this enables to gain access to proteins isolated from patient-derived samples in a reproducible efficient manner.  

We can proudly state that we have accelerated drug discovery pipelines of targets that were blocked in the past and we thrive in making the impossible possible.

Organisations we work with

Access to the PUXANO grid portfolio

Our cryoEM grid portfolio of metallic, carbon, multi-hole, tilted, tilted graphene and functionalized grids, is accessible for external parties via our collaboration model. 

Standard grid types, such as our PUXANO graphene grids, can be ordered and purchased as boxes of 20 grids, and are delivered within 2-4 weeks.   

Your trusted collaboration partner

PUXANO’s discovery platform is accessible via a flexible collaboration model that fits the partner’s needs. 

Our focus areas include vaccine or antibody development, small-molecule drug screening of challenging targets and advanced protein structure determination (proteins isolated from primary cells or patient-derived samples). Our platform has hereby been finetuned to membrane proteins (GPCRs, ion channels, glycoproteins, OMPs) and protein complexes (nucleoproteins). 

Whether you’re exploring new targets or scaling up discovery efforts, our flexible partnerships ensure seamless integration with your research and development goals.

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